Nuvaring and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuvaring (ethinyl estradiol; etonogestrel) and Aleve (naproxen sodium). Common drug interactions include pulmonary embolism among females.

The phase IV clinical study analyzes what interactions people have when they take Nuvaring and Aleve. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 11, 2026

96 people who take Nuvaring and Aleve together, and have interactions are studied.

What are the common drug interactions of Nuvaring and Aleve, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Abdominal pain lower
Dizziness
Folliculitis (infection of hair root)
Intervertebral disc protrusion (spinal disc protrusion)
Skin cancer
Fatigue (feeling of tiredness)
Migraine (headache)

male:

n/a

What are the common drug interactions of Nuvaring and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Murphy's sign positive
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Skin discolouration (change of skin colour)

20-29:

Drug ineffective
Abdominal pain
Abdominal pain lower
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Metrorrhagia (uterine bleeding at irregular intervals)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

30-39:

Blood pressure increased
Gait disturbance
Groin pain
Heart rate increased
Joint instability (a condition in which the joints aren't sufficiently supported)
Depression
Malaise (a feeling of general discomfort or uneasiness)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain

40-49:

Metrorrhagia (uterine bleeding at irregular intervals)
Asthenia (weakness)
Blindness unilateral
Chronic kidney disease
Depression
Device failure
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Nephrogenic anaemia (anaemia due to kidney disease)

50-59:

Folliculitis (infection of hair root)
Intervertebral disc protrusion (spinal disc protrusion)
Hot flush (sudden feelings of heat)
Mood swings (an extreme or rapid change in mood)
Radiculitis (inflammation of the spinal nerve roots)
Eyelid ptosis (falling of the upper or lower eyelid)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Hepatic cyst
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 20.83%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 15.62%
Migraine (headache): 8 people, 8.33%
Headache (pain in head): 6 people, 6.25%
Drowsiness: 6 people, 6.25%
Depression: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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