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Ofev and Tracleer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ofev (nintedanib esylate) and Tracleer (bosentan). Common drug interactions include dyspnoea among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Ofev and Tracleer. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,791 Ofev users. Check the latest studies of Ofev.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

On Jul, 09, 2026

38 people who take Ofev and Tracleer together, and have interactions are studied.

Ofev and Tracleer drug interactions.

What are the common drug interactions of Ofev and Tracleer, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Death
  3. Asthenia (weakness)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Cough
  6. Diarrhoea
  7. Dyspnoea exertional (breathlessness or shortness of breath)
  8. Dizziness
  9. Lung neoplasm malignant (cancer tumour of lung)
  10. Nausea (feeling of having an urge to vomit)

male:

  1. Death
  2. Diarrhoea
  3. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  4. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  5. Flushing (the warm, red condition of human skin)
  6. Gastrointestinal infection (infection of stomach and intestine)
  7. Headache (pain in head)
  8. Oxygen saturation decreased
  9. Pyrexia (fever)
  10. Body temperature increased

What are the common drug interactions of Ofev and Tracleer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Death

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Asthenia (weakness)
  3. Vomiting
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Chest pain
  6. Headache (pain in head)
  7. Lung neoplasm malignant (cancer tumour of lung)
  8. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  9. Abdominal discomfort
  10. Abdominal pain

What are the existing conditions these people have? *

  1. Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 23.68%
  2. Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Ofev and Tracleer?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ofev and Tracleer:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ofev:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tracleer:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ofev and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tracleer and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nintedanib esylate and bosentan (the active ingredients of Ofev and Tracleer, respectively), and Ofev and Tracleer (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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