Olanzapine and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Olanzapine (olanzapine) and Caffeine (caffeine). Common drug interactions include drug dependence among females and aplastic anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Olanzapine and Caffeine. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Olanzapine?

Olanzapine has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 69,242 Olanzapine users. Check the latest studies of Olanzapine.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

77 people who take Olanzapine and Caffeine together, and have interactions are studied.

Olanzapine and Caffeine drug interactions.

What are the common drug interactions of Olanzapine and Caffeine, by gender? *:

female:

Drug dependence
Necrosis (the death of body tissue)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Anaemia (lack of blood)
Heart rate increased
Melaena (the passage of black, tarry stools)
Overdose
Anxiety
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Cough

male:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Completed suicide (act of taking one's own life)
Ventricular fibrillation (abnormally irregular heart rhythm)
Salivary hypersecretion (excess saliva secretion)
Angioedema (rapid swelling of the dermis)
Apnoea (suspension of external breathing)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Circulatory collapse
Hypersensitivity

What are the common drug interactions of Olanzapine and Caffeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Angioedema (rapid swelling of the dermis)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Hypersensitivity
Oedema mouth (swelling of mouth)
Oral pain
Stomatitis (inflammation of mucous membrane of mouth)

20-29:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Cellulitis (infection under the skin)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Drug dependence
Necrosis (the death of body tissue)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Drug abuse
Electrocardiogram qt prolonged
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)

30-39:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Psychotic disorder
Sleep disorder
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Weight increased
White blood cell disorder
Anion gap increased
Anxiety
Depressed level of consciousness

40-49:

Chemotherapy
Diarrhoea
Drug abuse
Liver injury
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Overdose
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Surgery

50-59:

Drug level increased
Electrocardiogram qt prolonged
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Anaemia (lack of blood)
Melaena (the passage of black, tarry stools)
Cough
Drooling (drop saliva uncontrollably from the mouth)
Gait disturbance
Heart rate increased
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)

60+:

Agitation (state of anxiety or nervous excitement)
Ascites (accumulation of fluid in the abdominal cavity)
Dyspnoea (difficult or laboured respiration)
Eating disorder
Fall
Gait disturbance
Gastritis (inflammation of stomach)
Haematoma (collection of blood outside the blood vessels)
Hallucination (an experience involving the perception of something not present)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 13 people, 16.88%
Abdominal Discomfort: 11 people, 14.29%
Mood Swings (an extreme or rapid change in mood): 11 people, 14.29%
Rashes (redness): 11 people, 14.29%
Fever: 11 people, 14.29%
Insomnia (sleeplessness): 11 people, 14.29%
Mania (a state of abnormally elevated or irritable mood): 10 people, 12.99%
Pain: 10 people, 12.99%
Nausea (feeling of having an urge to vomit): 9 people, 11.69%
The Flu (the flu is caused by an influenza virus): 8 people, 10.39%

* Approximation only. Some reports may have incomplete information.

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