Oncaspar and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oncaspar (pegaspargase) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include hypertriglyceridaemia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Oncaspar and Hydroxyzine. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Oncaspar?

Oncaspar has active ingredients of pegaspargase. eHealthMe is studying from 5,504 Oncaspar users. Check the latest studies of Oncaspar.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 10, 2026

44 people who take Oncaspar and Hydroxyzine together, and have interactions are studied.

Oncaspar and Hydroxyzine drug interactions.

What are the common drug interactions of Oncaspar and Hydroxyzine, by gender? *:

female:

Hypertriglyceridaemia (excess of triglycerides in the blood)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Bone pain
Blood fibrinogen decreased
Drug hypersensitivity
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Abdominal pain
Appendicitis (inflammation of the appendix)
Coagulation factor v level decreased
Coagulation factor vii level decreased

male:

Pyrexia (fever)
Alanine aminotransferase increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Coagulopathy (blood's ability to clot is impaired)
Febrile neutropenia (fever with reduced white blood cells)
Erythema (redness of the skin)
Hyperammonaemia
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypofibrinogenaemia (a decrease in plasma fibrogen level)

What are the common drug interactions of Oncaspar and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

Gamma-glutamyltransferase increased
Hepatocellular injury (liver injury)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Erythema (redness of the skin)
Hyperammonaemia
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypofibrinogenaemia (a decrease in plasma fibrogen level)
Mucocutaneous ulceration (breaks in mucous membranes that are often accompanied by loss of tissue on the surface of mouth)

2-9:

Pyrexia (fever)
Drug hypersensitivity
Coagulation factor vii level decreased
Febrile neutropenia (fever with reduced white blood cells)
Hypofibrinogenaemia (a decrease in plasma fibrogen level)
Infection
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Staphylococcal infection (an infection with staphylococcus bacteria)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Leukopenia (less number of white blood cells in blood)

10-19:

Hypertriglyceridaemia (excess of triglycerides in the blood)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Alanine aminotransferase increased
Bone pain
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Abdominal pain
Appendicitis (inflammation of the appendix)
Blood bilirubin increased
Colitis (inflammation of colon)
Venoocclusive liver disease (small veins in the liver are obstructed)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 41 people, 93.18%
Nausea (feeling of having an urge to vomit): 24 people, 54.55%
Constipation: 16 people, 36.36%
Nausea And Vomiting: 14 people, 31.82%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 14 people, 31.82%
Fever: 13 people, 29.55%
Birth Control: 12 people, 27.27%
Oral Herpes (viral infection of mouth): 12 people, 27.27%
Pain: 9 people, 20.45%
Abdominal Pain: 7 people, 15.91%

* Approximation only. Some reports may have incomplete information.

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