Ondansetron and Proamatine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ondansetron (ondansetron) and Proamatine (midodrine hydrochloride). Common drug interactions include supraventricular tachycardia among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Ondansetron and Proamatine. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Ondansetron?

Ondansetron has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 122,739 Ondansetron users. Check the latest studies of Ondansetron.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

On Aug, 02, 2026

26 people who take Ondansetron and Proamatine together, and have interactions are studied.

Ondansetron and Proamatine drug interactions.

What are the common drug interactions of Ondansetron and Proamatine, by gender? *:

female:

Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Swelling
Tendonitis (a condition that causes pain and swelling of tendons)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary retention (the inability to completely or partially empty the bladder)
Acute respiratory failure
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bowel movement irregularity
Cardiac failure congestive

male:

Constipation
Drug ineffective
Basal ganglion degeneration (loss of brain tissue in the cortex, or outer layer of the brain)
Carotid arteriosclerosis (plaque deposition in artery)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Depression
Disturbance in attention

What are the common drug interactions of Ondansetron and Proamatine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adrenal disorder
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)

30-39:

n/a

40-49:

Intervertebral disc degeneration (spinal disc degeneration)
Lethargy (tiredness)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Migraine (headache)
Myelopathy (any neurologic deficit related to the spinal cord)
Personality disorder
Social problem
Spinal osteoarthritis (joint cartilage loss in spine)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)

50-59:

Angioimmunoblastic t-cell lymphoma stage iv (mature t-cell cancer of the blood or lymph vessel-stage iv)
Failure to thrive (inadequate weight gain and physical growth in children)

60+:

Constipation
Dyspnoea (difficult or laboured respiration)
Atelectasis (partial or complete collapse of the lung)
Brain natriuretic peptide increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Death
Dizziness
Drug hypersensitivity
Drug intolerance (drug sensitivity)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 6 people, 23.08%
High Blood Pressure: 6 people, 23.08%
Pain: 5 people, 19.23%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 4 people, 15.38%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 4 people, 15.38%
Anaemia (lack of blood): 4 people, 15.38%
Ascites (accumulation of fluid in the abdominal cavity): 4 people, 15.38%
Depression: 4 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
Hyperglycemia (high blood sugar): 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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