Opdivo and Mestinon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opdivo (nivolumab) and Mestinon (pyridostigmine bromide). Common drug interactions include cholelithiasis among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Opdivo and Mestinon. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

What is Mestinon?

Mestinon has active ingredients of pyridostigmine bromide. It is often used in myasthenia gravis. eHealthMe is studying from 5,948 Mestinon users. Check the latest studies of Mestinon.

On Jul, 21, 2026

12 people who take Opdivo and Mestinon together, and have interactions are studied.

What are the common drug interactions of Opdivo and Mestinon, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to peritoneum (cancer spreads to peritoneum)
Metastases to spleen (cancer spreads to spleen)
Splenic cyst (cyst on spleen or near by)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

male:

Pyrexia (fever)
Rash morbilliform (a rash that looks like measles)
Gamma-glutamyltransferase increased
Lacunar infarction (a type of stroke)
Miller fisher syndrome (a rare disorder that is characterized by abnormal muscle coordination)
Muscular weakness (muscle weakness)
Myocarditis (inflammation of heart muscle myocardium)
Neck pain
Spinal pain (pain in spine)
Ventricular extrasystoles (premature cardiac contraction)

What are the common drug interactions of Opdivo and Mestinon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pyrexia (fever)
Rash morbilliform (a rash that looks like measles)
Rash scarlatiniform (rash 3-5mm size)
Abdominal pain upper
Gamma-glutamyltransferase increased

50-59:

n/a

60+:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Spinal stenosis (narrowing of spinal column)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Lacunar infarction (a type of stroke)
Miller fisher syndrome (a rare disorder that is characterized by abnormal muscle coordination)
Muscular weakness (muscle weakness)
Myocarditis (inflammation of heart muscle myocardium)
Neck pain

What are the existing conditions these people have? *

Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 5 people, 41.67%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 5 people, 41.67%
Pain: 4 people, 33.33%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 1 person, 8.33%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 8.33%
Metastases To Liver (cancer spreads to liver): 1 person, 8.33%
Metastases To Bone (cancer spreads to bone): 1 person, 8.33%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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