Opsumit and Acetylcysteine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Acetylcysteine (acetylcysteine). Common drug interactions include peripheral swelling among females and lung transplant among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Acetylcysteine. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

On Jul, 08, 2026

30 people who take Opsumit and Acetylcysteine together, and have interactions are studied.

Opsumit and Acetylcysteine drug interactions.

What are the common drug interactions of Opsumit and Acetylcysteine, by gender? *:

female:

Peripheral swelling
Death
Haematocrit decreased
Pain
Peripheral vascular disorder
Platelet count decreased
Pleural effusion (water on the lungs)
Poor peripheral circulation
Surgery
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Lung transplant
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Oxygen consumption increased
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues)

What are the common drug interactions of Opsumit and Acetylcysteine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Lung transplant
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Oxygen consumption increased
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues)

60+:

Dyspnoea (difficult or laboured respiration)
Pneumonia
Platelet count decreased
Pleural effusion (water on the lungs)
Poor peripheral circulation
Surgery
Syncope (loss of consciousness with an inability to maintain postural tone)
Urinary retention (the inability to completely or partially empty the bladder)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 25 people, 83.33%
High Blood Pressure: 4 people, 13.33%
Rickets (softening of bones): 3 people, 10.00%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 6.67%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 6.67%
Oedema (fluid collection in tissue): 2 people, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.67%
Hypertensive Heart Disease: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Opsumit and Acetylcysteine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously