Opsumit and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Cevimeline (cevimeline hydrochloride). Common drug interactions include decreased appetite among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Cevimeline. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Jul, 27, 2026

34 people who take Opsumit and Cevimeline together, and have interactions are studied.

Opsumit and Cevimeline drug interactions.

What are the common drug interactions of Opsumit and Cevimeline, by gender? *:

female:

Decreased appetite
Drug ineffective
Dry throat
Dysphonia (speech disorder attributable to a disorder of phonation)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Eye disorder
Eye infection
Fall
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)

male:

Dyspnoea (difficult or laboured respiration)
Abdominal distension
Alanine aminotransferase increased
Aortic valve stenosis (narrowing of the aortic valve)
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Asthenia (weakness)
Blood albumin decreased
Blood alkaline phosphatase increased
Blood lactic acid increased

What are the common drug interactions of Opsumit and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Myalgia (muscle pain)
Abdominal distension
Abdominal discomfort
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Oropharyngeal pain
Productive cough

60+:

Dyspnoea (difficult or laboured respiration)
Pneumonia
Back pain
Chest discomfort
Cough
Dizziness
Drug ineffective
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 27 people, 79.41%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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