Opsumit and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Desyrel (trazodone hydrochloride). Common drug interactions include anaemia among females and abscess neck among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Desyrel. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

On Jul, 19, 2026

33 people who take Opsumit and Desyrel together, and have interactions are studied.

What are the common drug interactions of Opsumit and Desyrel, by gender? *:

female:

Anaemia (lack of blood)
Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial infection
Blood calcium decreased
Blood chloride decreased
Blood sodium decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbon dioxide decreased

male:

Abscess neck (neck abscesses)
Renal impairment (severely reduced kidney function)
Injection site erythema (redness at injection site)
Injection site induration
Injection site infection
Injection site inflammation
Injection site pain
Injection site swelling
Injection site warmth
Weight increased

What are the common drug interactions of Opsumit and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic respiratory failure
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Lung transplant
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory syncytial virus infection (viral disease of respiratory system)
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Abscess neck (neck abscesses)
Renal impairment (severely reduced kidney function)
Weight increased
Infusion site erythema (reddening of the skin at infusion site)
Infusion site inflammation
Infusion site pain
Infusion site swelling
Infusion site warmth
Infusion site infection
Infusion site induration

40-49:

Hypoxia (low oxygen in tissues)
Abdominal discomfort
Ageusia (loss of taste functions of the tongue)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Death
Decreased appetite
Diarrhoea
Headache (pain in head)
Multiple allergies (allergy to multiple agents)

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Corona virus infection (infection caused by a corona virus)
Hypokalaemia (low potassium)
Rhinovirus infection
Sputum discoloured
Wheezing (a high-pitched whistling sound made while you breath)
Hypotension (abnormally low blood pressure)
Pneumonia
Fluid overload (too much fluid in the blood)
Oedema (fluid collection in tissue)

60+:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Hypotension (abnormally low blood pressure)
Fatigue (feeling of tiredness)
Immobile (not moving)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nasopharyngitis (inflammation of the nasopharynx)
Oxygen consumption increased
Pain in extremity
Pericardial effusion (fluid around the heart)
Peripheral swelling

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 31 people, 93.94%
Wheezing (a high-pitched whistling sound made while you breath): 6 people, 18.18%
Injection Site Pain: 6 people, 18.18%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 15.15%
Pain: 4 people, 12.12%
Oedema (fluid collection in tissue): 4 people, 12.12%
Back Pain: 4 people, 12.12%
Gout (uric acid crystals building up in the body): 3 people, 9.09%
Depression: 3 people, 9.09%
Dyspnea (difficult or laboured breathing): 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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