Opsumit and Morphine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Morphine sulfate (morphine sulfate). Common drug interactions include swelling among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Morphine sulfate. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,262 Morphine sulfate users. Check the latest studies of Morphine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

75 people who take Opsumit and Morphine sulfate together, and have interactions are studied.

Opsumit and Morphine sulfate drug interactions.

What are the common drug interactions of Opsumit and Morphine Sulfate, by gender? *:

female:

Swelling
Death
Pain in jaw
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sinusitis (inflammation of sinus)
Anaemia (lack of blood)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fluid retention (an abnormal accumulation of fluid in the blood)
Oedema peripheral (superficial swelling)
Pulmonary oedema (fluid accumulation in the lungs)

male:

Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Lung adenocarcinoma recurrent (reoccurrence of a form of non-small cell lung cancer)
Metastases to kidney (cancer spreads to kidney)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Productive cough
Pulmonary congestion (congestion in the lungs)
Pulmonary mass
Renal cell carcinoma (a kidney cancer)

What are the common drug interactions of Opsumit and Morphine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain
Activities of daily living impaired
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood glucose fluctuation
Blood glucose increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Decreased appetite
Dehydration (dryness resulting from the removal of water)

30-39:

n/a

40-49:

Pulmonary oedema (fluid accumulation in the lungs)
Headache (pain in head)
Dry mouth
Malaise (a feeling of general discomfort or uneasiness)
Weight increased
Disease progression
Fluid retention (an abnormal accumulation of fluid in the blood)
Peripheral swelling
Pulmonary hypertension (increase in blood pressure in the lung artery)
Chills (felling of cold)

50-59:

Headache (pain in head)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Pain in jaw
Pyrexia (fever)
Scleroderma (hard skin)
Lactobacillus infection
Abdominal pain
Blood pressure fluctuation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Productive cough
Pyrexia (fever)
Vomiting
Hypotension (abnormally low blood pressure)
Blood pressure decreased
Bronchial secretion retention

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 59 people, 78.67%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.67%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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