Opsumit and Tresiba drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Tresiba (insulin degludec). Common drug interactions include pulmonary hypertension among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Tresiba. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Tresiba?

Tresiba has active ingredients of insulin degludec. It is often used in type 1 diabetes. eHealthMe is studying from 20,677 Tresiba users. Check the latest studies of Tresiba.

On Jul, 10, 2026

35 people who take Opsumit and Tresiba together, and have interactions are studied.

What are the common drug interactions of Opsumit and Tresiba, by gender? *:

female:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash
Right ventricular failure (right half of the heart fails to work)
Surgery
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight decreased
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Chest pain
Cardiac failure

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Cardiac discomfort
Arrhythmia (irregular heartbeat)
Ascites (accumulation of fluid in the abdominal cavity)
Diabetic foot
Diabetic foot infection
Oedema (fluid collection in tissue)
Osteomyelitis chronic (long lasting infection of bone marrow)
Fall
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

What are the common drug interactions of Opsumit and Tresiba, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Chest pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Cardiac failure
Dizziness
Hypoglycaemia (deficiency of glucose in the bloodstream)
Malaise (a feeling of general discomfort or uneasiness)
Extrasystoles
Atrial tachycardia (rhythm disturbance that arises in the atria)

40-49:

n/a

50-59:

Arrhythmia (irregular heartbeat)
Ascites (accumulation of fluid in the abdominal cavity)
Oedema (fluid collection in tissue)
Fall
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Blood glucose decreased
Chills (felling of cold)
Feeling cold
Malaise (a feeling of general discomfort or uneasiness)
Blood pressure decreased

60+:

Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Post procedural infection
Pulmonary oedema (fluid accumulation in the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tremor (trembling or shaking movements in one or more parts of your body)
Cough
Cardiac failure
Diabetic foot
Diabetic foot infection

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 31 people, 88.57%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 9 people, 25.71%
Diabetes: 7 people, 20.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 17.14%
Hypokalemia (low potassium): 6 people, 17.14%
Gastritis - Chronic (long lasting inflammation of stomach): 6 people, 17.14%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 6 people, 17.14%
Type 2 Diabetes: 3 people, 8.57%
Mesenteric Vein Thrombosis (blood clot in mesenteric vein): 3 people, 8.57%
Hepatitis C: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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