Optimark and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optimark (gadoversetamide) and Oxycontin (oxycodone hydrochloride). Common drug interactions include paraesthesia among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Optimark and Oxycontin. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

On Jul, 08, 2026

43 people who take Optimark and Oxycontin together, and have interactions are studied.

Optimark and Oxycontin drug interactions.

What are the common drug interactions of Optimark and Oxycontin, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin discolouration (change of skin colour)
Anxiety
Emotional distress
Injury
Skin hypopigmentation (loss of skin colour)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Skin ulcer
Joint swelling

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin induration (an abnormally hard spot or area on the skin)
Superior vena caval occlusion (obstruction of blood flow through the superior vena cava)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Skin discolouration (change of skin colour)
Joint contracture (a permanent shortening of a muscle or joint)
Skin hypertrophy (skin cells enlarges)
Anxiety
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)

What are the common drug interactions of Optimark and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Scar
Anger
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aphagia (inability or refusal to swallow)
Aphasia (damage to the parts of the brain that control language)

40-49:

Infection
Lividity (a tissue condition of being red or blue because of venous congestion, as in a contusion)
Muscle contracture (a permanent shortening of a muscle)
Oedema peripheral (superficial swelling)
Osteomyelitis (infection of bone)
Pruritus (severe itching of the skin)
Skin disorder (skin disease)
Skin fibrosis (fibrous tissue formation on skin)
Small intestinal obstruction (blockage in small intestine)
Steal syndrome (a symptom complex that occurs whenever there are extensive connection between 2 vascular beds, and the arterial supply to one of the beds is narrow or blocked, resulting in diversion of blood to the other vascular bed)

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc degeneration (spinal disc degeneration)
Lacunar infarction (a type of stroke)
Superior vena caval occlusion (obstruction of blood flow through the superior vena cava)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)

60+:

Anxiety
Depression
Renal impairment (severely reduced kidney function)
Scar
Skin hypertrophy (skin cells enlarges)
Dry eye (lack of adequate tears)
Emotional distress
Injury
Joint contracture (a permanent shortening of a muscle or joint)
Joint stiffness

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 20 people, 46.51%
Nuclear Magnetic Resonance Imaging Abdominal: 9 people, 20.93%
Haemorrhage Intracranial (bleeding within the skull): 8 people, 18.60%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 11.63%
Acute Kidney Failure: 5 people, 11.63%
Multiple Myeloma (cancer of the plasma cells): 4 people, 9.30%
Intervertebral Disc Protrusion (spinal disc protrusion): 4 people, 9.30%
Impaired Gastric Emptying: 4 people, 9.30%
Headache (pain in head): 4 people, 9.30%
Renal Vein Thrombosis (blood clot in renal vein): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

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