Optimark and Rocaltrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optimark (gadoversetamide) and Rocaltrol (calcitriol). Common drug interactions include pain among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Optimark and Rocaltrol. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

What is Rocaltrol?

Rocaltrol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is studying from 7,562 Rocaltrol users. Check the latest studies of Rocaltrol.

On Jul, 09, 2026

51 people who take Optimark and Rocaltrol together, and have interactions are studied.

Optimark and Rocaltrol drug interactions.

What are the common drug interactions of Optimark and Rocaltrol, by gender? *:

female:

Pain
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Gait disturbance
Joint range of motion decreased (disease of joint movement)
Skin tightness
Oedema peripheral (superficial swelling)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Anxiety

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin ulcer
Asthenia (weakness)
Back pain
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Generalised oedema (swelling all over the body)
Cardiac arrest
Discomfort
Muscular weakness (muscle weakness)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Optimark and Rocaltrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac arrest
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Endocardial fibrosis (cardiac fibrosis refers to an abnormal thickening of the heart valves)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint contracture (a permanent shortening of a muscle or joint)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Pain in extremity
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)

20-29:

Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Arthralgia (joint pain)
Back pain
Fall
Joint lock
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Peroneal nerve palsy
Vascular calcification (deposits of calcium in the blood vessels)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain
Emotional distress
Exfoliative rash (scaly red generalized skin rash)
Gait disturbance
Hyperkeratosis (thickening of the outer layer of the skin)
Joint range of motion decreased (disease of joint movement)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Hypoaesthesia (reduced sense of touch or sensation)
Oedema peripheral (superficial swelling)
Skin ulcer
Asthenia (weakness)
Pain in extremity
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Excoriation (to tear or wear off the skin of)
Exfoliative rash (scaly red generalized skin rash)

50-59:

Lower limb fracture
Pericardial effusion (fluid around the heart)
Pneumonia
Skin ulcer
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Arteriosclerosis (thickening and hardening of arteries)
Thermal burn (burn by heat)
Depression
Hypoaesthesia (reduced sense of touch or sensation)

60+:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Hyperkeratosis (thickening of the outer layer of the skin)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Rash papular (redness with papule)
Skin disorder (skin disease)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 26 people, 50.98%
Anaemia (lack of blood): 11 people, 21.57%
Nuclear Magnetic Resonance Imaging Abdominal: 11 people, 21.57%
Pain: 10 people, 19.61%
Joint Pain: 9 people, 17.65%
Catheter Related Complication: 8 people, 15.69%
High Blood Pressure: 8 people, 15.69%
Headache (pain in head): 7 people, 13.73%
Back Pain: 6 people, 11.76%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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