Optivar and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optivar (azelastine hydrochloride) and Singulair (montelukast sodium). Common drug interactions include dissociation among females and visual field defect among males.

The phase IV clinical study analyzes what interactions people have when they take Optivar and Singulair. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Optivar?

Optivar has active ingredients of azelastine hydrochloride. eHealthMe is studying from 367 Optivar users. Check the latest studies of Optivar.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

On Jul, 06, 2026

64 people who take Optivar and Singulair together, and have interactions are studied.

Optivar and Singulair drug interactions.

What are the common drug interactions of Optivar and Singulair, by gender? *:

female:

Dissociation
Drug effect delayed
Drug intolerance (drug sensitivity)
Dry eye (lack of adequate tears)
Dry mouth
Dyspnoea (difficult or laboured respiration)
Ear disorder
Embolism arterial (blood clot that has travelled through your arteries and become stuck)
Epistaxis (bleed from the nose)
Eye discharge

male:

Visual field defect
Abnormal behaviour
Epistaxis (bleed from the nose)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haematuria (presence of blood in urine)
Haemoglobin decreased
Hypersensitivity
Influenza like illness
Loss of consciousness
Peritonsillar abscess (painful pus filled inflammation of the tonsils and surrounding tissues)

What are the common drug interactions of Optivar and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Suicidal ideation
Visual field defect
Abdominal pain upper
Aggression
Depression
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Influenza
Intraocular pressure increased
Self-injurious ideation
Glaucoma (increased fluid pressure in the eye with vision loss)

10-19:

Abnormal behaviour
Biliary colic
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Suicide attempt
Gallbladder disorder
Injection site erythema (redness at injection site)
Injection site oedema
Injection site pruritus (severe itching at injection site)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Aphasia (damage to the parts of the brain that control language)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Complex partial seizures (epileptic seizure)
Confusional state
Deja vu (the experience of thinking that a new situation had occurred before)
Depression
Device expulsion
Dissociation
Dysphonia (speech disorder attributable to a disorder of phonation)

30-39:

Pain
Pain in extremity
Pain of skin
Paranasal sinus discomfort
Productive cough
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Sinus headache (headache caused by sinus infections)
Snoring
Surgery

40-49:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Sinusitis (inflammation of sinus)
Candidiasis (candidiasis or thrush is a fungal infection)
Skin irritation
Sunburn
Upper respiratory tract infection
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Pain
Erythema (redness of the skin)
Skin disorder (skin disease)

50-59:

Fall
Femur fracture
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Gait disturbance
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dyspepsia (indigestion)
Ear disorder
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Haematochezia (passage of stools containing blood)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Ovarian cancer metastatic (cancer of ovary spreads to other organ or parts)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.94%
Hypersensitivity: 6 people, 9.38%
Birth Control: 6 people, 9.38%
Pain: 5 people, 7.81%
Multiple Allergies (allergy to multiple agents): 5 people, 7.81%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 7.81%
The Flu (the flu is caused by an influenza virus): 4 people, 6.25%
Migraine (headache): 4 people, 6.25%
Immunodeficiency: 4 people, 6.25%
Depression: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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