Orencia and Avonex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orencia (abatacept) and Avonex (interferon beta 1a). Common drug interactions include influenza like illness among females and adrenal neoplasm among males.

The phase IV clinical study analyzes what interactions people have when they take Orencia and Avonex. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Orencia?

Orencia has active ingredients of abatacept. It is often used in rheumatoid arthritis. eHealthMe is studying from 135,415 Orencia users. Check the latest studies of Orencia.

What is Avonex?

Avonex has active ingredients of interferon beta 1a. It is often used in multiple sclerosis. eHealthMe is studying from 198,544 Avonex users. Check the latest studies of Avonex.



On Jul, 26, 2026

30 people who take Orencia and Avonex together, and have interactions are studied.

Orencia and Avonex drug interactions.

What are the common drug interactions of Orencia and Avonex, by gender? *:

female:

  1. Influenza like illness
  2. Maternal exposure during pregnancy (use of substance during pregnancy)
  3. Abnormal behaviour
  4. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  5. Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
  6. Arthralgia (joint pain)
  7. Pain in extremity
  8. Peripheral swelling
  9. Headache (pain in head)
  10. Gait disturbance

male:

  1. Adrenal neoplasm (abnormal growth of adrenal gland)
  2. Gallbladder disorder
  3. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  4. Influenza like illness
  5. Urinary tract infection
  6. Craniopharyngioma (a type of brain tumour derived from pituitary gland embryonic tissue)
  7. Haematuria (presence of blood in urine)
  8. Haemorrhage (bleeding)
  9. Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
  10. Pituitary tumour benign

What are the common drug interactions of Orencia and Avonex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Asthenia (weakness)
  2. Eosinophilia (eosinophil count in the peripheral blood exceeds)
  3. Hemiparesis (weakness on one side of the body)
  4. Influenza like illness
  5. Mobility decreased (ability to move is reduced)
  6. Overweight

20-29:

n/a

30-39:

  1. Visual acuity reduced (reduced clearness of vision)

40-49:

n/a

50-59:

  1. Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
  2. Influenza like illness
  3. Pituitary tumour benign
  4. Urinary tract infection
  5. Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
  6. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  7. Hypertension (high blood pressure)
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Anaemia (lack of blood)
  10. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

60+:

  1. Influenza like illness
  2. Arthralgia (joint pain)
  3. Erythema (redness of the skin)
  4. Eyelid ptosis (falling of the upper or lower eyelid)
  5. Feeling hot
  6. Gait disturbance
  7. General symptom
  8. Heart rate increased
  9. Hypertensive crisis
  10. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

  1. Muscle Spasms (muscle contraction): 3 people, 10.00%
  2. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.67%
  3. Gait Disturbance: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Orencia and Avonex?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Orencia and Avonex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Orencia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Avonex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Orencia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Avonex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on abatacept and interferon beta 1a (the active ingredients of Orencia and Avonex, respectively), and Orencia and Avonex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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