Orencia and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orencia (abatacept) and Rapamune (sirolimus). Common drug interactions include acne among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Orencia and Rapamune. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Orencia?

Orencia has active ingredients of abatacept. It is often used in rheumatoid arthritis. eHealthMe is studying from 135,415 Orencia users. Check the latest studies of Orencia.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 14, 2026

21 people who take Orencia and Rapamune together, and have interactions are studied.

What are the common drug interactions of Orencia and Rapamune, by gender? *:

female:

Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Ovarian cyst (fluid filled sac of the ovary)
Pain
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Transplant rejection (a transplant material is not worked)
Drug ineffective
C-reactive protein increased
Gastritis (inflammation of stomach)
Gravitational oedema (abnormally large fluid volume in the circulatory system makes obese)

male:

Pyrexia (fever)
Vomiting
Myalgia (muscle pain)
Pain
Platelet count decreased
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Rash
Rash pruritic (redness with itching)
Serum ferritin increased
White blood cell count decreased

What are the common drug interactions of Orencia and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain upper
Arthralgia (joint pain)
Dysuria (painful or difficult urination)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Vomiting

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Hepatic enzyme increased
Hypertension (high blood pressure)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Oesophagitis (inflammation of oesophagus)
Palpitations (feelings or sensations that your heart is pounding or racing)
Spinal pain (pain in spine)
Stress
Overdose

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 5 people, 23.81%
Transplant Rejection (a transplant material is not worked): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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