Orenitram and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orenitram (treprostinil) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include headache among females and device failure among males.

The phase IV clinical study analyzes what interactions people have when they take Orenitram and Hydroxyzine. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Orenitram?

Orenitram has active ingredients of treprostinil. eHealthMe is studying from 17,714 Orenitram users. Check the latest studies of Orenitram.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 29, 2026

44 people who take Orenitram and Hydroxyzine together, and have interactions are studied.

Orenitram and Hydroxyzine drug interactions.

What are the common drug interactions of Orenitram and Hydroxyzine, by gender? *:

female:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain
Cough
Nasopharyngitis (inflammation of the nasopharynx)
Diarrhoea
Dizziness
Pain in jaw
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Device failure
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Overdose
Oxygen saturation decreased
Pain
Pain in extremity
Rash
Retching (strong involuntary effort to vomit)
Vomiting

What are the common drug interactions of Orenitram and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Abdominal discomfort
Abdominal pain upper
Chest pain
Diarrhoea
Pain
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Headache (pain in head)
Cough
Pain
Diarrhoea
Nausea (feeling of having an urge to vomit)
Dizziness
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Coma (state of unconsciousness lasting more than six hours)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Upper respiratory tract infection
Connective tissue disorder (any disease that has the connective tissues of the body)
Disease progression
Dizziness
Dry mouth
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
General physical health deterioration (weak health status)
Localised oedema (fluid retention in a particular part of the body)
Oedema (fluid collection in tissue)

60+:

Hypotension (abnormally low blood pressure)
Dyspnoea (difficult or laboured respiration)
Urinary tract infection
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Fungal infection
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Weight decreased
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 42 people, 95.45%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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