Orenitram and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orenitram (treprostinil) and Sinemet (carbidopa; levodopa). Common drug interactions include syncope among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Orenitram and Sinemet. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Orenitram?

Orenitram has active ingredients of treprostinil. eHealthMe is studying from 17,714 Orenitram users. Check the latest studies of Orenitram.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 04, 2026

20 people who take Orenitram and Sinemet together, and have interactions are studied.

Orenitram and Sinemet drug interactions.

What are the common drug interactions of Orenitram and Sinemet, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Malaise (a feeling of general discomfort or uneasiness)
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Pain
Vomiting
Palpitations (feelings or sensations that your heart is pounding or racing)
Localised oedema (fluid retention in a particular part of the body)
Muscle spasms (muscle contraction)

male:

Fatigue (feeling of tiredness)
Gait disturbance
Faecaloma (hard mass of fecal matter)
Fall
Osteopenia (a condition where bone mineral density is lower than normal)
Tremor (trembling or shaking movements in one or more parts of your body)
Pain in jaw
Bone pain
Cardiac arrest
Cardiac failure congestive

What are the common drug interactions of Orenitram and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Syncope (loss of consciousness with an inability to maintain postural tone)
Malaise (a feeling of general discomfort or uneasiness)
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Pain
Vomiting
Palpitations (feelings or sensations that your heart is pounding or racing)
Localised oedema (fluid retention in a particular part of the body)
Muscle spasms (muscle contraction)

50-59:

n/a

60+:

Bone pain
Cardiac arrest
Death
Cardiac failure congestive
Cerebellar infarction (impaired blood circulation to cerebellum)
Concussion (short loss of normal brain function in response to a head injury)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Faecaloma (hard mass of fecal matter)
Fall

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 75.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 60.00%
Oedema (fluid collection in tissue): 4 people, 20.00%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.00%
Headache (pain in head): 1 person, 5.00%
Cardiac Failure: 1 person, 5.00%
Constipation: 1 person, 5.00%
Drug Hypersensitivity: 1 person, 5.00%
Dyspnea (difficult or laboured breathing): 1 person, 5.00%
Fever: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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