Orphenadrine citrate and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Orphenadrine citrate (orphenadrine citrate) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include arthralgia among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Orphenadrine citrate and Excedrin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Orphenadrine citrate?

Orphenadrine citrate has active ingredients of orphenadrine citrate. It is often used in muscle aches. eHealthMe is studying from 1,189 Orphenadrine citrate users. Check the latest studies of Orphenadrine citrate.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 26, 2026

12 people who take Orphenadrine citrate and Excedrin together, and have interactions are studied.

Orphenadrine citrate and Excedrin drug interactions.

What are the common drug interactions of Orphenadrine Citrate and Excedrin, by gender? *:

female:

Arthralgia (joint pain)
Bone disorder
Femur fracture
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mobility decreased (ability to move is reduced)
Osteoporotic fracture (fracture due to weak bone)
Pathological fracture (broken bone caused by disease)

male:

Chest pain
Hypoaesthesia (reduced sense of touch or sensation)
Haematoma (collection of blood outside the blood vessels)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mass
Mobility decreased (ability to move is reduced)
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscle injury
Osteoporotic fracture (fracture due to weak bone)
Pathological fracture (broken bone caused by disease)

What are the common drug interactions of Orphenadrine Citrate and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Bone disorder
Chronic kidney disease
Dysstasia (difficulty in standing)
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Groin pain

40-49:

n/a

50-59:

Arthralgia (joint pain)
Bone disorder
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Breast cancer in situ
Mass
Chest pain
Fall
Oestrogen receptor assay positive
Staphylococcal infection (an infection with staphylococcus bacteria)
Hypoaesthesia (reduced sense of touch or sensation)

60+:

n/a

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 41.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 25.00%
Secondary Hypothyroidism (pituitary gland and its failure to secrete tsh): 1 person, 8.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
Oestrogen Deficiency (lack of estrogens): 1 person, 8.33%
Migraine (headache): 1 person, 8.33%
Joint Swelling: 1 person, 8.33%
Growth Hormone Deficiency: 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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