Ortho tri-cyclen lo and Humira drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ortho tri-cyclen lo (ethinyl estradiol; norgestimate) and Humira (adalimumab). Common drug interactions include oropharyngeal pain among females.

The phase IV clinical study analyzes what interactions people have when they take Ortho tri-cyclen lo and Humira. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Ortho tri-cyclen lo?

Ortho tri-cyclen lo has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,787 Ortho tri-cyclen lo users. Check the latest studies of Ortho tri-cyclen lo.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 761,396 Humira users. Check the latest studies of Humira.



On Jul, 27, 2026

30 people who take Ortho tri-cyclen lo and Humira together, and have interactions are studied.

Ortho tri-cyclen lo and Humira drug interactions.

What are the common drug interactions of Ortho Tri-Cyclen Lo and Humira, by gender? *:

female:

  1. Oropharyngeal pain
  2. Arthralgia (joint pain)
  3. Skin discolouration (change of skin colour)
  4. Cough
  5. Pyrexia (fever)
  6. Chest pain
  7. Fatigue (feeling of tiredness)
  8. Lymphadenopathy (disease or enlargement of lymph nodes)
  9. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  10. Nephritis (inflammation of the nephrons in the kidneys)

male:

n/a

What are the common drug interactions of Ortho Tri-Cyclen Lo and Humira, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cough
  3. Respiratory disorder (respiratory disease)

20-29:

  1. Injection site erythema (redness at injection site)
  2. Injection site papule (solid pimple or swelling at injection site)
  3. Injection site pruritus (severe itching at injection site)
  4. Nausea (feeling of having an urge to vomit)
  5. Vomiting
  6. Abdominal pain
  7. Anaemia (lack of blood)
  8. Diarrhoea
  9. Injection site haematoma (localized swelling filled with blood at injection site)
  10. Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)

30-39:

  1. Oropharyngeal pain
  2. Arthralgia (joint pain)
  3. Skin discolouration (change of skin colour)
  4. Cough
  5. Pyrexia (fever)
  6. Chest pain
  7. Fatigue (feeling of tiredness)
  8. Lymphadenopathy (disease or enlargement of lymph nodes)
  9. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  10. Nephritis (inflammation of the nephrons in the kidneys)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 17 people, 56.67%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 10 people, 33.33%
  3. Inflammatory Bowel Disease: 9 people, 30.00%
  4. Cough: 7 people, 23.33%
  5. Stress And Anxiety: 3 people, 10.00%
  6. Pain: 2 people, 6.67%
  7. Migraine (headache): 2 people, 6.67%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.67%
  9. Depression: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho tri-cyclen lo and Humira?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ortho tri-cyclen lo and Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ortho tri-cyclen lo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ortho tri-cyclen lo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Humira and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate and adalimumab (the active ingredients of Ortho tri-cyclen lo and Humira, respectively), and Ortho tri-cyclen lo and Humira (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: