Osphena and Levoxyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Osphena (ospemifene) and Levoxyl (levothyroxine sodium). Common drug interactions include muscle spasms among females.

The phase IV clinical study analyzes what interactions people have when they take Osphena and Levoxyl. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Osphena?

Osphena has active ingredients of ospemifene. eHealthMe is studying from 2,762 Osphena users. Check the latest studies of Osphena.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

On Jul, 12, 2026

19 people who take Osphena and Levoxyl together, and have interactions are studied.

What are the common drug interactions of Osphena and Levoxyl, by gender? *:

female:

Muscle spasms (muscle contraction)
Dyspnoea (difficult or laboured respiration)
Impaired work ability
Influenza like illness
Joint dislocation (a joint position is changed from normal position)
Thrombosis (formation of a blood clot inside a blood vessel)
Tinnitus (a ringing in the ears)
Vision blurred
Asthenia (weakness)
Blood potassium decreased

male:

n/a

What are the common drug interactions of Osphena and Levoxyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Blindness transient (sudden loss of vision)
Fall
Foot fracture
Impaired work ability
Influenza like illness
Joint dislocation (a joint position is changed from normal position)
Thrombosis (formation of a blood clot inside a blood vessel)
Tinnitus (a ringing in the ears)
Vaginal discharge

60+:

Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Weight decreased
Oedema peripheral (superficial swelling)
Body temperature increased
Feeling hot
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood calcium increased
Cardiac flutter (abnormal heart rhythm)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)

What are the existing conditions these people have? *

Sexual Intercourse - Painful: 8 people, 42.11%
Vulvovaginal Dryness: 4 people, 21.05%
Atrophic Vulvovaginitis (inflammation of the vulva): 3 people, 15.79%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 3 people, 15.79%
Sleep Disorder: 3 people, 15.79%
Intracranial Aneurysm (bulging, weak area in the wall of a cranial artery): 3 people, 15.79%
Panic Disorder: 2 people, 10.53%
Familial Risk Factor: 2 people, 10.53%
High Blood Cholesterol: 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Osphena and Levoxyl?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously