Osphena and Progesterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Osphena (ospemifene) and Progesterone (progesterone). Common drug interactions include hot flush among females.

The phase IV clinical study analyzes what interactions people have when they take Osphena and Progesterone. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Osphena?

Osphena has active ingredients of ospemifene. eHealthMe is studying from 2,762 Osphena users. Check the latest studies of Osphena.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,021 Progesterone users. Check the latest studies of Progesterone.

On Jul, 08, 2026

27 people who take Osphena and Progesterone together, and have interactions are studied.

Osphena and Progesterone drug interactions.

What are the common drug interactions of Osphena and Progesterone, by gender? *:

female:

Hot flush (sudden feelings of heat)
Headache (pain in head)
Drug hypersensitivity
Arthralgia (joint pain)
Breast enlargement
Dysgeusia (disorder of the sense of taste)
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Limb discomfort (discomfort in leg)
Muscular weakness (muscle weakness)

male:

n/a

What are the common drug interactions of Osphena and Progesterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Breast enlargement
Breast tenderness

40-49:

Intervertebral disc protrusion (spinal disc protrusion)
Tendon rupture (tear of tendon)
Dyspareunia (painful sexual intercourse)

50-59:

Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Blood oestrogen decreased
Headache (pain in head)
Sex hormone binding globulin increased
Therapeutic response unexpected
Vulvovaginal burning sensation
Arthralgia (joint pain)
Dysgeusia (disorder of the sense of taste)
Insomnia (sleeplessness)

60+:

Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Poor quality sleep
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Vaginal discharge
Vision blurred
Visual impairment
Drug hypersensitivity
Pruritus (severe itching of the skin)
Abnormal sensation in eye

What are the existing conditions these people have? *

Sexual Intercourse - Painful: 9 people, 33.33%
Atrophic Vulvovaginitis (inflammation of the vulva): 4 people, 14.81%
Vulvovaginal Dryness: 2 people, 7.41%
Osteoporosis (bones weak and more likely to break): 2 people, 7.41%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 7.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.41%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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