Otezla and Cosopt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Cosopt (dorzolamide hydrochloride; timolol maleate). Common drug interactions include bronchitis among females and skin lesion among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Cosopt. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,253 Otezla users. Check the latest studies of Otezla.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

On Apr, 22, 2026

20 people who take Otezla and Cosopt together, and have interactions are studied.

What are the common drug interactions of Otezla and Cosopt, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
C-reactive protein increased
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug ineffective
Drug intolerance (drug sensitivity)
Hepatic enzyme increased
Hypersensitivity
Hypertension (high blood pressure)
Limb discomfort (discomfort in leg)

male:

Skin lesion
Behcet's syndrome (involves inflammation of the blood vessels)
Iritis (painful inflammation of the iris of the eye)
Pain
Psoriasis (immune-mediated disease that affects the skin)
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Rash
Stomatitis (inflammation of mucous membrane of mouth)

What are the common drug interactions of Otezla and Cosopt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Malaise (a feeling of general discomfort or uneasiness)
Skin lesion

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
C-reactive protein increased
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)
Hepatic enzyme increased
Hypersensitivity
Hypertension (high blood pressure)

40-49:

n/a

50-59:

Diarrhoea

60+:

Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Limb discomfort (discomfort in leg)
Pneumonia
Skin reaction
Synovitis (inflammation of the synovial membrane)
Thyroid disorder (thyroid diseases)
Vomiting
Alopecia (absence of hair from areas of the body)
Thyroxine decreased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 50.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 35.00%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 25.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 10.00%
Nausea (feeling of having an urge to vomit): 1 person, 5.00%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 5.00%
High Blood Pressure: 1 person, 5.00%
Diabetes: 1 person, 5.00%
Behcet's Syndrome (involves inflammation of the blood vessels): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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