Otezla and Evista drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Evista (raloxifene hydrochloride). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Evista. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Evista?

Evista has active ingredients of raloxifene hydrochloride. It is often used in osteoporosis. eHealthMe is studying from 25,891 Evista users. Check the latest studies of Evista.

On Jul, 25, 2026

37 people who take Otezla and Evista together, and have interactions are studied.

What are the common drug interactions of Otezla and Evista, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Urinary tract infection
Dyspepsia (indigestion)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Adverse event
Ankle fracture
Asthenia (weakness)
Blood triglycerides increased
Contusion (a type of hematoma of tissue in which capillaries)

male:

n/a

What are the common drug interactions of Otezla and Evista, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Asthenia (weakness)
Gait disturbance
Migraine (headache)

50-59:

Ankle fracture
Fall

60+:

Nausea (feeling of having an urge to vomit)
Diarrhoea
High density lipoprotein decreased
Low density lipoprotein increased (cholesterol increased in blood)
Psoriasis (immune-mediated disease that affects the skin)
Retching (strong involuntary effort to vomit)
Skin exfoliation (removal of the oldest dead skin cells)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 18 people, 48.65%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 13 people, 35.14%
High Blood Pressure: 4 people, 10.81%
High Blood Cholesterol: 3 people, 8.11%
Urinary Tract Infection: 2 people, 5.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.41%
Pustular Psoriasis (raised bumps on the skin that are filled with pus): 2 people, 5.41%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
Hyperthyroidism (over activity of the thyroid gland): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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