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Otezla and Naprelan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Naprelan (naproxen sodium). Common drug interactions include fall among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Naprelan. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Naprelan?

Naprelan has active ingredients of naproxen sodium. eHealthMe is studying from 731 Naprelan users. Check the latest studies of Naprelan.

On Jul, 15, 2026

15 people who take Otezla and Naprelan together, and have interactions are studied.

Otezla and Naprelan drug interactions.

What are the common drug interactions of Otezla and Naprelan, by gender? *:

female:

  1. Fall
  2. Rash
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Somnolence (a state of near-sleep, a strong desire for sleep)
  5. Blood albumin decreased
  6. Surgical failure
  7. Bladder cancer
  8. Psychotic disorder
  9. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  10. Abdominal distension

male:

  1. Headache (pain in head)

What are the common drug interactions of Otezla and Naprelan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Gastrointestinal disorder (functional problems of gastrointestinal tract)

50-59:

  1. Bladder cancer

60+:

  1. Ankle fracture
  2. Brain injury
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Somnolence (a state of near-sleep, a strong desire for sleep)
  5. Surgical failure
  6. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  7. Fall
  8. Headache (pain in head)
  9. Intervertebral disc protrusion (spinal disc protrusion)
  10. Nerve injury

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 66.67%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 26.67%
  3. Stress And Anxiety: 1 person, 6.67%
  4. Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.67%
  5. Pain: 1 person, 6.67%
  6. Joint Pain: 1 person, 6.67%
  7. Apnea (temporary absence or cessation of breathing): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Otezla and Naprelan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Otezla and Naprelan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Otezla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naprelan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Otezla and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naprelan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on apremilast and naproxen sodium (the active ingredients of Otezla and Naprelan, respectively), and Otezla and Naprelan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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