Otezla and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Rapamune (sirolimus). Common drug interactions include psoriasis among females.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Rapamune. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

11 people who take Otezla and Rapamune together, and have interactions are studied.

What are the common drug interactions of Otezla and Rapamune, by gender? *:

female:

Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Drug ineffective
Gastric disorder (disease of stomach)
Heart valve incompetence (heart's valves do not work correctly)
Herpes zoster
Respiratory disorder (respiratory disease)
Rash
Alopecia (absence of hair from areas of the body)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

male:

n/a

What are the common drug interactions of Otezla and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Psoriasis (immune-mediated disease that affects the skin)
Rash
Depression suicidal (suicide depressive disorder)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Heart valve incompetence (heart's valves do not work correctly)
Herpes zoster

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 9 people, 81.82%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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