Otezla and Sprintec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Sprintec (ethinyl estradiol; norgestimate). Common drug interactions include nausea among females and psoriasis among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Sprintec. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

On Jul, 21, 2026

70 people who take Otezla and Sprintec together, and have interactions are studied.

What are the common drug interactions of Otezla and Sprintec, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Rash
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Arthralgia (joint pain)
Back pain
Drug ineffective
Tension headache
Burning sensation

male:

Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Otezla and Sprintec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal discomfort
Frequent bowel movements

20-29:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Psoriasis (immune-mediated disease that affects the skin)
Abdominal discomfort
Abdominal pain upper
Diarrhoea
Erythema (redness of the skin)
Skin irritation

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting
Psoriasis (immune-mediated disease that affects the skin)
Abdominal discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Sinusitis (inflammation of sinus)
Arthralgia (joint pain)
Back pain
Diarrhoea
Headache (pain in head)

40-49:

Psoriasis (immune-mediated disease that affects the skin)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Headache (pain in head)
Rash
Infection
Muscle spasms (muscle contraction)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Joint effusion (presence of extra fluid in joint covering)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 50 people, 71.43%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 8 people, 11.43%
Immunodeficiency Common Variable: 5 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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