Otrexup and Actemra drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Otrexup (methotrexate) and Actemra (tocilizumab). Common drug interactions include drug ineffective among females and sinusitis among males.
The phase IV clinical study analyzes what interactions people have when they take Otrexup and Actemra. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.
What is Otrexup?
Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.
What is Actemra?
Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.
32 people who take Otrexup and Actemra together, and have interactions are studied.
What are the common drug interactions of Otrexup and Actemra, by gender? *:
female:
- Drug ineffective
- Hepatic enzyme increased
- Pain
- Malaise (a feeling of general discomfort or uneasiness)
- Anxiety
- Chest discomfort
- Cough
- Dyspnoea (difficult or laboured respiration)
- Panic attack
- Dizziness
male:
- Sinusitis (inflammation of sinus)
- Back pain
- Pain in extremity
- Interstitial lung disease
- Death
- Drug ineffective
- Hand deformity
- Insomnia (sleeplessness)
- Limb discomfort (discomfort in leg)
- Liver disorder (liver diseases)
What are the common drug interactions of Otrexup and Actemra, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Anxiety
- Chest discomfort
- Cough
- Dyspnoea (difficult or laboured respiration)
- Panic attack
20-29:
n/a
30-39:
n/a
40-49:
- Abdominal discomfort
- Alopecia (absence of hair from areas of the body)
- Arthropathy
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Discomfort
- Drug ineffective
- Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
- Hepatic enzyme increased
- Hypersensitivity
- Pain
50-59:
- Pneumonia
- Arthralgia (joint pain)
- Deformity (disfigurement)
- Drug hypersensitivity
- Drug ineffective
- Hepatotoxicity (chemical-driven liver damage)
- Ill-defined disorder
- Loss of consciousness
- Malaise (a feeling of general discomfort or uneasiness)
- Mobility decreased (ability to move is reduced)
60+:
- Drug ineffective
- Fall
- Weight decreased
- Abdominal pain upper
- Alanine aminotransferase increased
- Alopecia (absence of hair from areas of the body)
- Anxiety
- Appendicitis (inflammation of the appendix)
- Arthralgia (joint pain)
- Aspartate aminotransferase increased
What are the existing conditions these people have? *
- Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 15.62%
* Approximation only. Some reports may have incomplete information.
Do you take Otrexup and Actemra?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Otrexup and Actemra:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Otrexup:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Actemra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Otrexup and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Actemra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
- Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on methotrexate and tocilizumab (the active ingredients of Otrexup and Actemra, respectively), and Otrexup and Actemra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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