Otrexup and Cosentyx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otrexup (methotrexate) and Cosentyx (secukinumab). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Otrexup and Cosentyx. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

What is Cosentyx?

Cosentyx has active ingredients of secukinumab. It is often used in psoriatic arthritis. eHealthMe is studying from 187,247 Cosentyx users. Check the latest studies of Cosentyx.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

45 people who take Otrexup and Cosentyx together, and have interactions are studied.

What are the common drug interactions of Otrexup and Cosentyx, by gender? *:

female:

Drug ineffective
Pain
Nasopharyngitis (inflammation of the nasopharynx)
Hepatitis c
Malaise (a feeling of general discomfort or uneasiness)
Swelling
Neuropathy peripheral (surface nerve damage)
Restless legs syndrome (a powerful urge to move your legs)
Pain in extremity
Abdominal pain upper

male:

Drug ineffective
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Diarrhoea
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Cryptococcosis (potentially fatal fungal disease)
Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
Drug intolerance (drug sensitivity)
Seronegative arthritis (a joint disease negative for rheumatoid arthritis)

What are the common drug interactions of Otrexup and Cosentyx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Oral candidiasis (fungal infection of mouth)
Staphylococcal infection (an infection with staphylococcus bacteria)

50-59:

Drug ineffective

60+:

Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Fall
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Kidney infection
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Pneumonia

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 25 people, 55.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 31.11%
Seronegative Arthritis (a joint disease negative for rheumatoid arthritis): 6 people, 13.33%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 13.33%
Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful): 6 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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