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Oxervate and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxervate (cenegermin-bkbj) and Aleve (naproxen sodium). Common drug interactions include eye pain among females and eye pain among males.

The phase IV clinical study analyzes what interactions people have when they take Oxervate and Aleve. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Oxervate?

Oxervate has active ingredients of cenegermin-bkbj. eHealthMe is studying from 7,219 Oxervate users. Check the latest studies of Oxervate.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 31, 2026

27 people who take Oxervate and Aleve together, and have interactions are studied.

Oxervate and Aleve drug interactions.

What are the common drug interactions of Oxervate and Aleve, by gender? *:

female:

  1. Eye pain
  2. Eye swelling
  3. Eye irritation
  4. Vision blurred
  5. Eye pruritus (eye itching)
  6. Intraocular pressure increased
  7. Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
  8. Ocular hyperaemia (an abnormally large amount of blood in eye)
  9. Migraine (headache)
  10. Vomiting

male:

  1. Eye pain
  2. Photophobia (extreme sensitivity to light)
  3. Eyelid pain
  4. Facial pain
  5. Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
  6. Surgery
  7. Vision blurred
  8. Eye irritation
  9. Ocular hyperaemia (an abnormally large amount of blood in eye)
  10. Corneal perforation (small hole in a cornea)

What are the common drug interactions of Oxervate and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Corneal perforation (small hole in a cornea)
  2. Eye pain
  3. Eye swelling
  4. Lacrimation increased
  5. Ocular hyperaemia (an abnormally large amount of blood in eye)
  6. Photophobia (extreme sensitivity to light)
  7. Vision blurred

60+:

  1. Eye irritation
  2. Eye pain
  3. Ocular hyperaemia (an abnormally large amount of blood in eye)
  4. Surgery
  5. Eye pruritus (eye itching)
  6. Eye swelling
  7. Intraocular pressure increased
  8. Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
  9. Abdominal pain upper
  10. Blood glucose increased

What are the existing conditions these people have? *

  1. Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 24 people, 88.89%
  2. Hypoaesthesia Eye (reduced sense of touch or sensation on eyes): 11 people, 40.74%
  3. Ulcerative Keratitis (ulcerative inflammation of the cornea): 6 people, 22.22%

* Approximation only. Some reports may have incomplete information.

Do you take Oxervate and Aleve?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Oxervate and Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxervate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Oxervate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aleve and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on cenegermin-bkbj and naproxen sodium (the active ingredients of Oxervate and Aleve, respectively), and Oxervate and Aleve (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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