Oxycodone and acetaminophen and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride) and Actos (pioglitazone hydrochloride). Common drug interactions include disorientation among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and acetaminophen and Actos. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 19, 2026

57 people who take Oxycodone and acetaminophen and Actos together, and have interactions are studied.

Oxycodone and acetaminophen and Actos drug interactions.

What are the common drug interactions of Oxycodone And Acetaminophen and Actos, by gender? *:

female:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Dystonia (abnormal muscle tone)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Endocarditis (inflammation in heart muscle)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fatigue (feeling of tiredness)
Femur fracture

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Bone pain
Cardiac disorder
Drug abuse
Drug resistance (reduction in effectiveness of a drug)
Eye disorder
Fall
Fatigue (feeling of tiredness)
Heart valve incompetence (heart's valves do not work correctly)

What are the common drug interactions of Oxycodone And Acetaminophen and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Vomiting
Blindness
Bone density decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Femoral arterial stenosis (narrowing of artery of femur bone)
Memory impairment
Obesity (having too much body fat)
Pain in extremity
Renal disorder (kidney disease)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Atrioventricular block complete (heart block complete)
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)
Obesity (having too much body fat)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress

60+:

Asthenia (weakness)
Fall
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Confusional state
Device failure
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 31.58%
Nausea (feeling of having an urge to vomit): 14 people, 24.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 19.30%
Sleep Disorder: 10 people, 17.54%
High Blood Cholesterol: 10 people, 17.54%
Depression: 9 people, 15.79%
Type 2 Diabetes: 8 people, 14.04%
Constipation: 8 people, 14.04%
Muscle Spasms (muscle contraction): 8 people, 14.04%

* Approximation only. Some reports may have incomplete information.

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