Oxycodone and acetaminophen and Flector drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride) and Flector (diclofenac epolamine). Common drug interactions include chronic kidney disease among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and acetaminophen and Flector. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Flector?

Flector has active ingredients of diclofenac epolamine. It is often used in pain. eHealthMe is studying from 5,112 Flector users. Check the latest studies of Flector.

On Jul, 06, 2026

32 people who take Oxycodone and acetaminophen and Flector together, and have interactions are studied.

Oxycodone and acetaminophen and Flector drug interactions.

What are the common drug interactions of Oxycodone And Acetaminophen and Flector, by gender? *:

female:

Chronic kidney disease
Fatigue (feeling of tiredness)
Drug ineffective
Neuropathy peripheral (surface nerve damage)
Pneumonia
Renal failure (kidney dysfunction)
Ankle fracture
Aphonia (inability to produce voice)
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)

male:

Malaise (a feeling of general discomfort or uneasiness)
Drug ineffective
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone pain
Disability
Drug resistance (reduction in effectiveness of a drug)
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

What are the common drug interactions of Oxycodone And Acetaminophen and Flector, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site rash
Peripheral swelling

40-49:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac disorder
Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ankle fracture
Cardiac failure
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abdominal distension
Death
Diarrhoea
Gout (uric acid crystals building up in the body)
Hepatic steatosis (fatty liver disease)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Facial pain
Fatigue (feeling of tiredness)
Food intolerance (inability to have food)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Glossodynia (a burning or painful sensation in the tongue)
Oropharyngeal pain
Overdose

What are the existing conditions these people have? *

High Blood Cholesterol: 11 people, 34.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 34.38%
Cardiac Disorder: 8 people, 25.00%
Sleep Disorder: 7 people, 21.88%
Hypersensitivity: 6 people, 18.75%
Stress And Anxiety: 6 people, 18.75%
Infection: 5 people, 15.62%
Inflammation: 5 people, 15.62%
Dyspnea (difficult or laboured breathing): 5 people, 15.62%
Nausea (feeling of having an urge to vomit): 5 people, 15.62%

* Approximation only. Some reports may have incomplete information.

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