Oxycodone hydrochloride and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone hydrochloride (oxycodone hydrochloride) and Hydroxyurea (hydroxyurea). Common drug interactions include mouth ulceration among females and acute chest syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone hydrochloride and Hydroxyurea. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

On Jul, 07, 2026

51 people who take Oxycodone hydrochloride and Hydroxyurea together, and have interactions are studied.

Oxycodone hydrochloride and Hydroxyurea drug interactions.

What are the common drug interactions of Oxycodone Hydrochloride and Hydroxyurea, by gender? *:

female:

Mouth ulceration (mouth ulcers)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyrexia (fever)
Rash pruritic (redness with itching)
Sinusitis (inflammation of sinus)
Splenic rupture
Stomatitis (inflammation of mucous membrane of mouth)
Therapeutic response decreased (less preventive response)

male:

Acute chest syndrome (acute chest pain, fever and difficulty breathing)
Diarrhoea
Chronic kidney disease
Chronic myelomonocytic leukaemia (cancers of the blood-forming cells of the bone marrow)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dry skin
Duodenitis (inflammation of the duodenum)
Dysplasia (enlargement of an organ or tissue)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the common drug interactions of Oxycodone Hydrochloride and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Acute chest syndrome (acute chest pain, fever and difficulty breathing)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)
Skin hypopigmentation (loss of skin colour)
Therapeutic response unexpected
Thrombocytopenia (decrease of platelets in blood)
Blood pressure increased
Bone pain
Chest discomfort
Dry skin

30-39:

Diarrhoea
Abdominal discomfort
Abdominal pain
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Abdominal discomfort
Chest pain
Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Haemorrhage intracranial (bleeding within the skull)
Pneumonia

50-59:

Colonic pseudo-obstruction (severe impairment in the ability of the intestines to push food through)
Decreased appetite
Wound
Wound infection

60+:

Respiratory failure (inadequate gas exchange by the respiratory system)
Chest pain
Anisocytosis (patient's red blood cells are of unequal size)
Arrhythmia (irregular heartbeat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease
Chronic myelomonocytic leukaemia (cancers of the blood-forming cells of the bone marrow)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea

What are the existing conditions these people have? *

Haemochromatosis (body to absorb more iron than usual from food): 9 people, 17.65%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 8 people, 15.69%
Splenomegaly (enlargement of spleen): 6 people, 11.76%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 7.84%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 7.84%
Rickets (softening of bones): 3 people, 5.88%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 5.88%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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