Oxycodone hydrochloride and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone hydrochloride (oxycodone hydrochloride) and Keppra (levetiracetam). Common drug interactions include lower respiratory tract infection among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone hydrochloride and Keppra. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 12, 2026

78 people who take Oxycodone hydrochloride and Keppra together, and have interactions are studied.

Oxycodone hydrochloride and Keppra drug interactions.

What are the common drug interactions of Oxycodone Hydrochloride and Keppra, by gender? *:

female:

Lower respiratory tract infection
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pleuritic pain
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Pyuria (a condition of urine containing pus)

male:

Blood pressure increased
Urinary tract infection
Benign prostatic hyperplasia (benign enlargement of the prostate)
Body temperature decreased
Cardiac failure congestive
Catheter site haemorrhage (bleeding at catheter site)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cough
Death

What are the common drug interactions of Oxycodone Hydrochloride and Keppra, by age (0-1 to 60+)? *:

0-1:

Body temperature decreased
Catheter site haemorrhage (bleeding at catheter site)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cough
Death
Dyspnoea (difficult or laboured respiration)
Ear infection
Erythema (redness of the skin)
Furuncle (infection of the hair follicle)
Heart rate decreased

2-9:

n/a

10-19:

Abdominal pain
Balance disorder
Constipation
Death
Dehydration (dryness resulting from the removal of water)
Febrile neutropenia (fever with reduced white blood cells)
Nausea (feeling of having an urge to vomit)
Renal cyst (kidney cyst)
Vomiting

20-29:

Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug hypersensitivity
Drug ineffective
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Completed suicide (act of taking one's own life)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Arthralgia (joint pain)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dry skin
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

40-49:

Leukocytosis (increased white blood cells)
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Muscle spasms (muscle contraction)
Nephrolithiasis (calculi in the kidneys)
Pleuritic pain
Pyuria (a condition of urine containing pus)
Swelling

50-59:

Chest pain
Cough
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Expressive language disorder
Fatigue (feeling of tiredness)
Fibrin d dimer increased
Hypersomnia (excessive daytime sleepiness (eds))
Insomnia (sleeplessness)

60+:

Pneumonia
Blood pressure increased
Rib fracture
Traumatic lung injury
Drug dependence
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Overdose
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 14.10%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 14.10%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.26%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 5.13%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.13%
Immunodeficiency Common Variable: 4 people, 5.13%
Drowsiness: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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