Oxycodone and Cefixime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and Cefixime (cefixime). Common drug interactions include skin ulcer among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and Cefixime. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Cefixime?

Cefixime has active ingredients of cefixime. eHealthMe is studying from 3,237 Cefixime users. Check the latest studies of Cefixime.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

81 people who take Oxycodone and Cefixime together, and have interactions are studied.

Oxycodone and Cefixime drug interactions.

What are the common drug interactions of Oxycodone and Cefixime, by gender? *:

female:

Skin ulcer
Drug intolerance (drug sensitivity)
Gait disturbance
Osteoporosis (bones weak and more likely to break)
Skin lesion
Tooth abscess (pus formation in tooth)
Vaginal infection
Constipation
Foot fracture
Multiple fractures

male:

Fatigue (feeling of tiredness)
Bacteraemia (presence of bacteria in the blood)
Headache (pain in head)
Neck pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Speech disorder
Urinary tract infection
Anaemia (lack of blood)
Diarrhoea
Osteomyelitis (infection of bone)

What are the common drug interactions of Oxycodone and Cefixime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Small intestinal obstruction (blockage in small intestine)
Stomatitis (inflammation of mucous membrane of mouth)
White blood cell count decreased

20-29:

Drug ineffective
Drug intolerance (drug sensitivity)
Skin lesion
Tooth abscess (pus formation in tooth)
Vaginal infection
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Pelvic abscess
Perineal abscess
Scrotal abscess (pus in scrotum)
Scrotal gangrene (death of scrotum cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)

40-49:

Cryptococcosis (potentially fatal fungal disease)
Device related infection
Infection
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Infusion site pruritus (severe itching at infusion site)
Post procedural haematoma (post procedural clotting of blood)
Pruritus (severe itching of the skin)
Sinusitis (inflammation of sinus)
Skin ulcer

50-59:

Renal injury (kidney injury)
Death
Malaise (a feeling of general discomfort or uneasiness)
Oedema peripheral (superficial swelling)
Pneumonia
Weight increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress

60+:

Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Arthralgia (joint pain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Dysgraphia (impaired ability to learn to write)
Mouth ulceration (mouth ulcers)
Neck pain
Speech disorder

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 8.64%
Osteoporosis (bones weak and more likely to break): 6 people, 7.41%
Hiv Infection: 6 people, 7.41%
Primary Immunodeficiency Syndrome: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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