Oxycodone and Janumet xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and Janumet xr (metformin hydrochloride; sitagliptin phosphate). Common drug interactions include chronic sinusitis among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and Janumet xr. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Janumet xr?

Janumet xr has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in type 2 diabetes. eHealthMe is studying from 2,357 Janumet xr users. Check the latest studies of Janumet xr.

On Aug, 13, 2026

24 people who take Oxycodone and Janumet xr together, and have interactions are studied.

Oxycodone and Janumet xr drug interactions.

What are the common drug interactions of Oxycodone and Janumet Xr, by gender? *:

female:

Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Hereditary angioedema (recurrent episodes of severe swelling)
Malaise (a feeling of general discomfort or uneasiness)
Abscess (pus)
Cellulitis (infection under the skin)
Depression
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Ulcer haemorrhage (bleeding ulcer)

male:

Vomiting
Acidosis (build-up of carbon dioxide in the blood)
Cardiomegaly (increased size of heart than normal)
Chronic kidney disease
Diarrhoea
Heart valve incompetence (heart's valves do not work correctly)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperkalaemia (damage to or disease of the kidney)
Ivth nerve paralysis (fourth nerve paralysis due to weakness of the nerve)
Loss of consciousness

What are the common drug interactions of Oxycodone and Janumet Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Acidosis (build-up of carbon dioxide in the blood)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac disorder
Diarrhoea
Dizziness
Eye pain
Halo vision (rainbow vision)

60+:

Abscess (pus)
Cellulitis (infection under the skin)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Hereditary angioedema (recurrent episodes of severe swelling)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 20.83%
Immunodeficiency Common Variable: 4 people, 16.67%
Asthma: 4 people, 16.67%
Type 2 Diabetes: 3 people, 12.50%
Weight Decreased: 2 people, 8.33%
Hypotension (abnormally low blood pressure): 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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