Oxycodone and L-lysine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and L-lysine (lysine). Common drug interactions include vomiting among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and L-lysine. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is L-lysine?

L-lysine has active ingredients of lysine. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 1,560 L-lysine users. Check the latest studies of L-lysine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

25 people who take Oxycodone and L-lysine together, and have interactions are studied.

Oxycodone and L-lysine drug interactions.

What are the common drug interactions of Oxycodone and L-Lysine, by gender? *:

female:

Vomiting
Blood potassium decreased
Diarrhoea
Flatulence (flatus expelled through the anus)
Foaming at mouth (excess saliva secretion)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Peripheral swelling
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abnormal faeces (abnormal stool)

male:

Confusional state
Diarrhoea
Dizziness
Drug dependence
Dry mouth
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Oxycodone and L-Lysine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Rectal haemorrhage (bleeding from anus)
Abdominal distension
Anxiety
Decreased appetite
Depression
Fatigue (feeling of tiredness)

50-59:

Blood potassium decreased
Diarrhoea
Foaming at mouth (excess saliva secretion)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Peripheral swelling
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vomiting
Abnormal faeces (abnormal stool)
Blood sodium decreased

60+:

Headache (pain in head)
Vision blurred
Dementia (madness)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug dependence
Dry mouth
Flushing (the warm, red condition of human skin)
Hospitalisation
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 36.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 32.00%
Rashes (redness): 5 people, 20.00%
Depression: 5 people, 20.00%
Neuropathy Peripheral (surface nerve damage): 5 people, 20.00%
Nausea (feeling of having an urge to vomit): 5 people, 20.00%
High Blood Pressure: 5 people, 20.00%
Seasonal Allergy (allergic condition due to certain season): 4 people, 16.00%
Back Pain: 4 people, 16.00%
Constipation: 4 people, 16.00%

* Approximation only. Some reports may have incomplete information.

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