Oxycodone and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and Macitentan (macitentan). Common drug interactions include renal failure among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and Macitentan. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,591 Oxycodone users. Check the latest studies of Oxycodone.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Feb, 10, 2026

38 people who take Oxycodone and Macitentan together, and have interactions are studied.

Oxycodone and Macitentan drug interactions.

What are the common drug interactions of Oxycodone and Macitentan, by gender? *:

female:

Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skin ulcer
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery
Swelling
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased

male:

Febrile neutropenia (fever with reduced white blood cells)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Fluid retention (an abnormal accumulation of fluid in the blood)
Iron deficiency anaemia
Lung transplant
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Oxycodone and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Drug ineffective
Death
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Left ventricular failure (left ventricle fails to contract forcefully)
Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Right ventricular failure (right half of the heart fails to work)

40-49:

Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypervolaemia (abnormally increased volume of blood)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Melaena (the passage of black, tarry stools)
Occult blood positive
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary oedema (fluid accumulation in the lungs)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Nausea (feeling of having an urge to vomit)
Connective tissue disorder (any disease that has the connective tissues of the body)
Lung disorder (lung disease)
Pain in jaw
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary veno-occlusive disease (obstructive disease of the pulmonary veins)
Abdominal distension
Alanine aminotransferase increased
Aspartate aminotransferase increased

60+:

Flatulence (flatus expelled through the anus)
Headache (pain in head)
Pruritus (severe itching of the skin)
Renal pain (kidney pain)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Hypoxia (low oxygen in tissues)
Memory impairment
Weight increased
Abdominal distension

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 27 people, 71.05%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 23.68%
Insomnia (sleeplessness): 8 people, 21.05%
Oedema (fluid collection in tissue): 4 people, 10.53%
Embolism Venous (embolus may pass into the arterial system): 4 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.89%
Mucosal Inflammation (infection of mucous membrane): 3 people, 7.89%
Fever: 3 people, 7.89%
Diarrhea: 3 people, 7.89%
Diabetes: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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