Oxycodone and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include post-traumatic stress disorder among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and Odefsey. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Aug, 06, 2026

71 people who take Oxycodone and Odefsey together, and have interactions are studied.

Oxycodone and Odefsey drug interactions.

What are the common drug interactions of Oxycodone and Odefsey, by gender? *:

female:

Post-traumatic stress disorder
Postural reflex impairment
Psychiatric symptom
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Restlessness (not able to rest)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Rhinorrhoea (watery mucus discharge from the nose)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation

male:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal injury (kidney injury)
Bone pain
Dysstasia (difficulty in standing)
Ankle fracture
Arthralgia (joint pain)
Balance disorder
Decreased activity
Hypertension (high blood pressure)

What are the common drug interactions of Oxycodone and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Foot fracture
Hand fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Bone pain
Depression
Vitamin d deficiency

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Chronic kidney disease
Depression
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Blood creatinine increased
Bone density decreased
Fear

50-59:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteopenia (a condition where bone mineral density is lower than normal)
Bone density decreased
Chronic kidney disease
Depression
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Renal impairment (severely reduced kidney function)

60+:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hypertension (high blood pressure)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Osteopenia (a condition where bone mineral density is lower than normal)
Ankle fracture
Arthralgia (joint pain)
Bone pain
Depressed mood
Diarrhoea

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 14.08%
High Blood Cholesterol: 6 people, 8.45%
Depression: 6 people, 8.45%
Erection Problems: 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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