Oxycodone and Propacet 100 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone (oxycodone hydrochloride) and Propacet 100 (acetaminophen; propoxyphene napsylate). Common drug interactions include respiratory distress among females and erectile dysfunction among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and Propacet 100. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,591 Oxycodone users. Check the latest studies of Oxycodone.

What is Propacet 100?

Propacet 100 has active ingredients of acetaminophen; propoxyphene napsylate. eHealthMe is studying from 1,282 Propacet 100 users. Check the latest studies of Propacet 100.

On Feb, 02, 2026

19 people who take Oxycodone and Propacet 100 together, and have interactions are studied.

Oxycodone and Propacet 100 drug interactions.

What are the common drug interactions of Oxycodone and Propacet 100, by gender? *:

female:

Respiratory distress (difficulty in breathing)
Secretion discharge
Tremor (trembling or shaking movements in one or more parts of your body)
Upper respiratory tract infection
Urine sodium increased
Vomiting
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Large intestine perforation (hole in large intestine)
Abnormal behaviour
Angiopathy (generic term for a disease of the blood vessels)

male:

Erectile dysfunction
Arthralgia (joint pain)
Blood amylase increased
Blood carbon dioxide decreased
Cardiac disorder
Coronary artery stenosis (narrowing of coronary artery)
Dehydration (dryness resulting from the removal of water)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

What are the common drug interactions of Oxycodone and Propacet 100, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Influenza like illness

30-39:

n/a

40-49:

Abnormal behaviour
Arthralgia (joint pain)
Brain neoplasm (tumour of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Constipation
Depression
Difficulty in walking
Drug ineffective
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

50-59:

Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Erectile dysfunction
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Injection site bruising
Injection site burning
Injection site erythema (redness at injection site)
Myalgia (muscle pain)
Nephrolithiasis (calculi in the kidneys)

60+:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Large intestine perforation (hole in large intestine)
Blood amylase increased
Blood carbon dioxide decreased
Breast cancer
Cardiac disorder
Coronary artery stenosis (narrowing of coronary artery)
Dehydration (dryness resulting from the removal of water)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 15.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 15.79%
Depression: 3 people, 15.79%
Insomnia (sleeplessness): 3 people, 15.79%
Ill-Defined Disorder: 2 people, 10.53%
Quit Smoking: 2 people, 10.53%
Birth Control: 1 person, 5.26%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 5.26%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.26%
Diabetes: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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