Qsymia and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Qsymia (phentermine hydrochloride; topiramate) and Oxycodone (oxycodone hydrochloride). Common drug interactions include sinusitis among females and hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Qsymia and Oxycodone. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Qsymia?

Qsymia has active ingredients of phentermine hydrochloride; topiramate. It is often used in weight loss. eHealthMe is studying from 4,530 Qsymia users. Check the latest studies of Qsymia.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Feb, 10, 2026

15 people who take Qsymia and Oxycodone together, and have interactions are studied.

What are the common drug interactions of Qsymia and Oxycodone, by gender? *:

female:

Sinusitis (inflammation of sinus)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Joint dislocation (a joint position is changed from normal position)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Decreased interest
Depressed mood
Frequent bowel movements
Memory impairment
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

male:

Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Fall
Muscle spasms (muscle contraction)
Rib fracture
Tinnitus (a ringing in the ears)
Abdominal pain
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood iron decreased
Concussion (short loss of normal brain function in response to a head injury)

What are the common drug interactions of Qsymia and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Dry mouth
Dysgeusia (disorder of the sense of taste)
Pruritus (severe itching of the skin)
Sinusitis (inflammation of sinus)
Erythema (redness of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Local swelling (swelling at the site of some application of substance or injury)
Swelling
Swelling face
Tinnitus (a ringing in the ears)

What are the existing conditions these people have? *

Weight Decreased: 6 people, 40.00%
High Blood Cholesterol: 5 people, 33.33%
High Blood Pressure: 5 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 26.67%
Stress And Anxiety: 4 people, 26.67%
Back Pain: 3 people, 20.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 20.00%
Inflammation: 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Constipation: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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