Oxycontin and Depakene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycontin (oxycodone hydrochloride) and Depakene (valproic acid). Common drug interactions include deep vein thrombosis among females and interstitial lung disease among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycontin and Depakene. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

On Jul, 25, 2026

66 people who take Oxycontin and Depakene together, and have interactions are studied.

Oxycontin and Depakene drug interactions.

What are the common drug interactions of Oxycontin and Depakene, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Delirium (wild excitement)
Infection
Nausea (feeling of having an urge to vomit)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Bacteraemia (presence of bacteria in the blood)
Disease progression
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Hyperhidrosis (abnormally increased sweating)

male:

Interstitial lung disease
Disease progression
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Insomnia (sleeplessness)
Lymphangiosis carcinomatosa (inflammation of the lymph vessels can lead to cancer)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Anxiety
Aspartate aminotransferase increased

What are the common drug interactions of Oxycontin and Depakene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Histiocytosis haematophagic
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
White blood cell count decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

Anxiety
Depression
Drug addiction
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fall
Insomnia (sleeplessness)
Laceration (tearing of soft body tissue)
Loss of consciousness
Alcoholism (problems with alcohol)

40-49:

Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Hepatic failure (liver failure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Insomnia (sleeplessness)
Lung disorder (lung disease)
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Nausea (feeling of having an urge to vomit)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)

50-59:

Pyrexia (fever)
Constipation
Somnolence (a state of near-sleep, a strong desire for sleep)
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Delirium (wild excitement)
Infection
Nausea (feeling of having an urge to vomit)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)

60+:

Disease progression
Neutropenia (an abnormally low number of neutrophils)
Non-small cell lung cancer (type of epithelial lung cancer)
Oesophageal ulcer (ulcer of oesophagus)
Proctitis ulcerative (inflammation of the rectum and anus ulcerative)
Thrombosis (formation of a blood clot inside a blood vessel)
Atypical femur fracture
Blood uric acid increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Delirium (wild excitement)

What are the existing conditions these people have? *

Cancer Pain: 14 people, 21.21%
Rectal Cancer (cancer of rectum): 6 people, 9.09%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 6 people, 9.09%
Renal Cell Carcinoma (a kidney cancer): 5 people, 7.58%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 7.58%
Constipation: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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