Oxycontin and Rexulti drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycontin (oxycodone hydrochloride) and Rexulti (brexpiprazole). Common drug interactions include pneumonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycontin and Rexulti. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

On Jul, 11, 2026

19 people who take Oxycontin and Rexulti together, and have interactions are studied.

Oxycontin and Rexulti drug interactions.

What are the common drug interactions of Oxycontin and Rexulti, by gender? *:

female:

Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Depression
Eye swelling
Face injury
Fall
Haemorrhage (bleeding)
Immune system disorder
Lymphoedema (localized fluid retention and tissue swelling)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Tooth loss
Drug screen positive
Dyskinesia (abnormality or impairment of voluntary movement)
Heart rate increased
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Panic attack
Tremor (trembling or shaking movements in one or more parts of your body)

What are the common drug interactions of Oxycontin and Rexulti, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Heart rate increased
Balance disorder
Blood pressure increased
Diplopia (double vision)
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Inappropriate affect
Incontinence (lack of moderation or self-control)
Muscle contractions involuntary (uncontrolled muscle contraction)
Nervousness

40-49:

Constipation
Nausea (feeling of having an urge to vomit)

50-59:

Renal failure (kidney dysfunction)
Foot fracture
Drug screen positive
Dyskinesia (abnormality or impairment of voluntary movement)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Panic attack
Tremor (trembling or shaking movements in one or more parts of your body)
Antisocial behaviour
Depression

60+:

Malaise (a feeling of general discomfort or uneasiness)
Plasma cell myeloma (cancer that begins in plasma cells)
Pneumonia

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 31.58%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 26.32%
Hiv Infection: 4 people, 21.05%
Stress And Anxiety: 1 person, 5.26%
Sleep Disorder: 1 person, 5.26%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.26%
Panic Disorder: 1 person, 5.26%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%
Herniated Nucleus Pulposus (Slipped Disk): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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