Ozempic and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Aleve (naproxen sodium). Common drug interactions include hypophagia among females and blood pressure decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Aleve. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 17, 2026

48 people who take Ozempic and Aleve together, and have interactions are studied.

What are the common drug interactions of Ozempic and Aleve, by gender? *:

female:

Hypophagia (reduced food intake)
Incontinence (lack of moderation or self-control)
Injection site pain
Irritable bowel syndrome
Kidney infection
Localised infection (infection at the single location)
Memory impairment
Migraine (headache)
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

Blood pressure decreased
Abdominal distension
Chest pain
Constipation
Cough
Diabetic ulcer
Discomfort
Dizziness
Drug ineffective
Dyspepsia (indigestion)

What are the common drug interactions of Ozempic and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Irritable bowel syndrome
Migraine (headache)
Ovarian cyst (fluid filled sac of the ovary)
Thyroid cyst

30-39:

Sepsis (a severe blood infection that can lead to organ failure and death)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abscess limb (limb infection)
Anal abscess
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Scrotal abscess (pus in scrotum)

40-49:

Drug ineffective
Nephrolithiasis (calculi in the kidneys)
Back pain
Blood cholesterol increased
Impaired work ability
Inflammation
Fatigue (feeling of tiredness)
Kidney infection
Localised infection (infection at the single location)
Mobility decreased (ability to move is reduced)

50-59:

Abdominal discomfort
Abdominal distension
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chest pain
Dermatitis allergic (inflammation of the skin due allergic reaction)
Discomfort
Drug ineffective
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Flatulence (flatus expelled through the anus)

60+:

Pain in extremity
Arthralgia (joint pain)
Diarrhoea
Drug ineffective
Fatigue (feeling of tiredness)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Injection site discolouration
Knee arthroplasty
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Diabetes: 7 people, 14.58%
High Blood Pressure: 6 people, 12.50%
Type 2 Diabetes: 5 people, 10.42%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.42%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 8.33%
Joint Pain: 4 people, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 6.25%
Nausea (feeling of having an urge to vomit): 3 people, 6.25%
Migraine (headache): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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