Ozempic and Caplyta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Caplyta (lumateperone tosylate). Common drug interactions include constipation among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Caplyta. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

What is Caplyta?

Caplyta has active ingredients of lumateperone tosylate. eHealthMe is studying from 3,109 Caplyta users. Check the latest studies of Caplyta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

12 people who take Ozempic and Caplyta together, and have interactions are studied.

What are the common drug interactions of Ozempic and Caplyta, by gender? *:

female:

Constipation
Dyskinesia (abnormality or impairment of voluntary movement)
Hypersensitivity
Abdominal pain upper
Asthenia (weakness)
Blood pressure decreased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cataract (clouding of the lens inside the eye)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Anxiety

What are the common drug interactions of Ozempic and Caplyta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cataract (clouding of the lens inside the eye)
Dry mouth
Fatigue (feeling of tiredness)
Memory impairment
Pneumonia
Thirst

30-39:

Catatonia (unresponsive to external stimuli)
Drooling (drop saliva uncontrollably from the mouth)
Dysarthria (speech disorder)
Hypersensitivity

40-49:

Constipation
Dyspnoea (difficult or laboured respiration)
Gastric ulcer (stomach ulcer)
Tardive dyskinesia (a disorder that involves involuntary movements)
Anxiety

50-59:

Dyskinesia (abnormality or impairment of voluntary movement)
Abdominal pain upper
Diarrhoea
Vomiting

60+:

Asthenia (weakness)
Blood pressure decreased
Loss of consciousness
Somnolence (a state of near-sleep, a strong desire for sleep)
Dizziness
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fear
Feeling drunk

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 7 people, 58.33%
Type 2 Diabetes: 4 people, 33.33%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 16.67%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 1 person, 8.33%
Drowsiness: 1 person, 8.33%
Birth Control: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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