Ozempic and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Macitentan (macitentan). Common drug interactions include malaise among females.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Macitentan. It is created by eHealthMe based on reports of 10 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Apr, 27, 2026

10 people who take Ozempic and Macitentan together, and have interactions are studied.

Ozempic and Macitentan drug interactions.

What are the common drug interactions of Ozempic and Macitentan, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Fatigue (feeling of tiredness)
Hospitalisation
Infection
Back pain
Bone pain
Decreased appetite
Device dislocation
Device related infection
Diarrhoea

male:

n/a

What are the common drug interactions of Ozempic and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Injection site erythema (redness at injection site)
Injection site pain
Pain in jaw

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Chills (felling of cold)
Fatigue (feeling of tiredness)
Device dislocation
Device related infection
Menopause delayed (late end of monthly cycles)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Pain
Pruritus (severe itching of the skin)
Rash pruritic (redness with itching)
Skin haemorrhage (bleeding into skin)
Weight decreased
Dyspnoea exertional (breathlessness or shortness of breath)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 70.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 20.00%
Glycosylated Haemoglobin Increased: 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

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