Ozempic and Phentermine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Phentermine (phentermine hydrochloride). Common drug interactions include nausea among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Phentermine. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

On Jul, 18, 2026

54 people who take Ozempic and Phentermine together, and have interactions are studied.

Ozempic and Phentermine drug interactions.

What are the common drug interactions of Ozempic and Phentermine, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Infusion related reaction
Rash
Sinusitis (inflammation of sinus)
Headache (pain in head)
Vomiting
Dehydration (dryness resulting from the removal of water)

male:

Rash
Megacolon (a very dilated colon)
Skin disorder (skin disease)
Tremor (trembling or shaking movements in one or more parts of your body)
Dehydration (dryness resulting from the removal of water)
Electrolyte imbalance
Hip fracture
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the common drug interactions of Ozempic and Phentermine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injection site inflammation
Injection site swelling
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pruritus (severe itching of the skin)
Rash
Skin erosion (a discontinuity of the skin)
Conjunctivitis (pink eye)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Drug ineffective
Dry eye (lack of adequate tears)

20-29:

Groin infection (infection in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Soft tissue infection
Anal abscess
Anxiety
Depression
Genital abscess (build up of pus in genital)

30-39:

Vomiting
Adverse drug reaction
Asthma
Diarrhoea
Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Immunodeficiency
Injection site pain
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)

40-49:

Dehydration (dryness resulting from the removal of water)
Ear infection
Fatigue (feeling of tiredness)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Headache (pain in head)
Megacolon (a very dilated colon)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Infusion site hypersensitivity

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Hypertension (high blood pressure)
Mitral valve disease (disease of mitral valve of heart)
Palpitations (feelings or sensations that your heart is pounding or racing)
Nausea (feeling of having an urge to vomit)
Rash
Dehydration (dryness resulting from the removal of water)
Diarrhoea

60+:

Rash
Dehydration (dryness resulting from the removal of water)
Vaginal haemorrhage (vaginal bleeding)
Adverse event
Alopecia (absence of hair from areas of the body)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Dysphonia (speech disorder attributable to a disorder of phonation)
Heart rate irregular
Hip fracture
Knee arthroplasty

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 11.11%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 11.11%
Immunodeficiency Common Variable: 6 people, 11.11%
Diabetes: 5 people, 9.26%
Weight Decreased: 4 people, 7.41%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.56%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 5.56%
Asthma: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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