Ozempic and Zopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Zopiclone (eszopiclone). Common drug interactions include hypersensitivity among females and disturbance in attention among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Zopiclone. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,331 Zopiclone users. Check the latest studies of Zopiclone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

75 people who take Ozempic and Zopiclone together, and have interactions are studied.

Ozempic and Zopiclone drug interactions.

What are the common drug interactions of Ozempic and Zopiclone, by gender? *:

female:

Hypersensitivity
Hypertension (high blood pressure)
Lacrimation increased
Lower respiratory tract infection
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Multiple fractures
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)

male:

Disturbance in attention
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Depression
Drug level above therapeutic
Dysstasia (difficulty in standing)
Emotional distress
Gait disturbance
General physical health deterioration (weak health status)
Heart rate increased
Infusion related reaction

What are the common drug interactions of Ozempic and Zopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Abdominal pain upper
Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Drug level decreased
Frequent bowel movements
Gastroenteritis (inflammation of stomach and intestine)
Pain

40-49:

Flushing (the warm, red condition of human skin)

50-59:

Frequent bowel movements
Gastrointestinal pain
Hospitalisation
Injury
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mobility decreased (ability to move is reduced)
Pain
Tinnitus (a ringing in the ears)
Type 2 diabetes mellitus

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting
Arthralgia (joint pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis (inflammation of colon)
Cough
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Pain in extremity
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 13.33%
Secondary Immunodeficiency (lack of immunity due to some disease): 9 people, 12.00%
Pain: 9 people, 12.00%
High Blood Pressure: 9 people, 12.00%
Sinusitis (inflammation of sinus): 8 people, 10.67%
Diabetes: 8 people, 10.67%
Sleep Disorder: 7 people, 9.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 8.00%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 8.00%
Type 2 Diabetes: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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