Pamelor and Evista drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pamelor (nortriptyline hydrochloride) and Evista (raloxifene hydrochloride). Common drug interactions include cardiac failure among females.

The phase IV clinical study analyzes what interactions people have when they take Pamelor and Evista. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

What is Evista?

Evista has active ingredients of raloxifene hydrochloride. It is often used in osteoporosis. eHealthMe is studying from 25,891 Evista users. Check the latest studies of Evista.

On Jul, 07, 2026

20 people who take Pamelor and Evista together, and have interactions are studied.

What are the common drug interactions of Pamelor and Evista, by gender? *:

female:

Cardiac failure
Nausea (feeling of having an urge to vomit)
Haematoma (collection of blood outside the blood vessels)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Increased appetite
Platelet count decreased
Soft tissue injury
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)

male:

n/a

What are the common drug interactions of Pamelor and Evista, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac failure
Hypoaesthesia (reduced sense of touch or sensation)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Increased appetite
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Blood pressure decreased
Coma (state of unconsciousness lasting more than six hours)
Dizziness
Feeling hot
Localised skin reaction (skin reaction at single location)
Rash erythematous (redness of the skin)

60+:

Bone density decreased
Acute myocardial infarction (acute heart attack)
Haematoma (collection of blood outside the blood vessels)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypercalciuria (elevated calcium (ca+) level in the urine)
Hypertension (high blood pressure)
Osteitis deformans (a disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain)
Protein total increased
Soft tissue injury
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 4 people, 20.00%
Pain: 2 people, 10.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Depression: 2 people, 10.00%
Affective Disorder (mental disorder): 2 people, 10.00%
Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 1 person, 5.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 5.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.00%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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