Pamelor and Prinivil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pamelor (nortriptyline hydrochloride) and Prinivil (lisinopril). Common drug interactions include dyspepsia among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Pamelor and Prinivil. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

What is Prinivil?

Prinivil has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 20,152 Prinivil users. Check the latest studies of Prinivil.

On Jul, 06, 2026

81 people who take Pamelor and Prinivil together, and have interactions are studied.

What are the common drug interactions of Pamelor and Prinivil, by gender? *:

female:

Dyspepsia (indigestion)
Mood swings (an extreme or rapid change in mood)
Nightmare (unpleasant dream)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Fibroadenoma of breast (breast lump)
Hypotension (abnormally low blood pressure)
Ventricular extrasystoles (premature cardiac contraction)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Drug ineffective

male:

Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pneumonia
Thrombosis (formation of a blood clot inside a blood vessel)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Stress
Arrhythmia (irregular heartbeat)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Pamelor and Prinivil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Dizziness
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Vomiting
White blood cell count decreased

40-49:

Anxiety
Cardiac failure congestive
Congestive cardiomyopathy (weakening of heart muscle)
Dyspepsia (indigestion)
Mood swings (an extreme or rapid change in mood)
Nightmare (unpleasant dream)
Fibroadenoma of breast (breast lump)
Ventricular extrasystoles (premature cardiac contraction)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Gastrointestinal tract adenoma (a benign tumour (-oma) of glandular origin in digestive tract)

50-59:

Cardiomegaly (increased size of heart than normal)
Chills (felling of cold)
Hypotension (abnormally low blood pressure)
Influenza
Organ failure
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Productive cough
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Diarrhoea
Palpitations (feelings or sensations that your heart is pounding or racing)
Chest pain
Cold sweat
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Drug ineffective
Emotional distress
Thrombosis (formation of a blood clot inside a blood vessel)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the existing conditions these people have? *

Pain: 19 people, 23.46%
Type 2 Diabetes: 10 people, 12.35%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 10 people, 12.35%
Neuralgia (pain in one or more nerves): 10 people, 12.35%
Meralgia Paraesthetica (a neurological (nerve) condition that causes pain in the outer thigh): 10 people, 12.35%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 10 people, 12.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.88%
Neuropathic Arthropathy (a progressive destruction of bone and joints): 6 people, 7.41%
Insomnia (sleeplessness): 6 people, 7.41%
Diarrhea: 6 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Pamelor and Prinivil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously